Research
Foundation
YWHAG
ABOUT YWHAG
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YWHAG genetic mutation is a rare neurological disorder that affects a small but growing number of children and adults worldwide. This gene provides instructions for making a protein called 14-3-3 gamma-- it is highly expressed in the brain and plays a critical role in a wide range of cellular processes including signal transduction, cell cycle regulation, and protein trafficking. The genetic mutation alters the structure and function of 14-3-3 gamma protein.
Symptoms and severity vary among patients, including seizures, developmental delays, behavioral issues and more. Early involvement is crucial to help give children a chance to develop normally.
NEWLY DIAGNOSED - GET INVOLVED
NEWLY DIAGNOSED
You are not alone. Check out our resources and get connected.
WHAT IS YWHAG
What is the YWHAG genetic mutation, and how does it affect you?
ON GOING RESEARCH
Our goal is to support and start new research into the YWHAG mutation.
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INVOLVED
Your involvement and donation is crucial to our success.
YWHAG UPDATES
STATUS REPORT SPRING 2026
Research Update: Observational Study for Drug Repurposing
Through the Foundation’s drug repurposing efforts, Lovastatin was identified as a promising candidate after small-molecule screening and RNA sequencing studies showed it may help shift abnormal gene expression toward a more typical pattern in YWHAG-mutant cells . ...
WHY SUPPORT MATTERS
In the United States, approximately 25 million individuals are afflicted with a rare disease. The global estimate for this number is believed to be around 400 million. Explore the statistics related to rare diseases, including the challenges they present, and then click the button below to find out how you can extend your support to those affected specifically by the YWHAG genetic mutation.
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