The YWHAG Foundation is proud to highlight a growing body of scientific research dedicated to understanding the YWHAG gene and its protein product, 14-3-3 γ. Over the past few years, new publications have shed light on the fundamental biology of 14-3-3γ, its role in brain development, neuronal signaling, and how mutations in this critical scaffolding protein leads to epilepsy, developmental delays, and other neurological symptoms. These studies span a range of discoveries from identifying how specific variants disrupt protein interactions and signaling pathways, to uncovering new regulatory mechanisms that impact 14-3-3γ’s stability and function.

 

Each new publication represents a step forward in unraveling the mechanisms behind YWHAG related disorders and brings the scientific community closer to potential therapeutic strategies. By compiling these research updates in one place, the Foundation aims to make cutting-edge discoveries more accessible to families, clinicians, and researchers, fostering collaboration and accelerating progress toward meaningful treatments.